Bone morphogenetic protein-10 (BMP-10) compositions
AssigneeGenetics Institute, Inc.
InventorsAnthony J. Celeste, John M. Wozney
Life of this patent
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Abstract
Purified Bone Morphogenetic Protein-10 (BMP-10) proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
Claims9
A purified bone morphogenetic protein-10(BMP-10) polypeptide consisting of the amino acid sequence from amino acid #1 to amino acid #108 as set forth in SEQ ID NO:
- 11.
A purified bone morphogenetic protein-10(BMP-10) polypeptide, wherein said polypeptide is a dimer wherein one subunit comprises at least the amino acid sequence from amino acid #1 to amino acid #108 of SEQ ID NO:
- 11, and one subunit comprises art amino acid sequence for a bone morphogenetic protein selected from the group consisting BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8 and BMP-9.
A purified bone morphogenetic protein-10(BMP-10) protein produced by the steps of
- (a) culturing a mammalian cell transformed with a DNA comprising the nucleotide sequence from nucleotide #1108 to #1431 as shown in SEQ ID NO:
- 10;
- and
- (b) recovering and purifying from said culture medium a protein comprising the amino acid sequence from amino acid #1 to amino acid #108 as shown in SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.