Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders
AssigneeGenentech, Inc.
InventorsClaire M. Doerschuk, Sherman Fong, Caroline Alice Hebert, Kyung Jin Kim, Steven R. Leong
Life of this patent
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Abstract
Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
Claims12
An anti-IL-8 monoclonal antibody, wherein the antibody comprises an antigen binding site comprising the complementarity determining regions of the light chain polypeptide of FIG. 24 (SEQ ID NO:48) and the complementarity determining regions of the heavy chain polypeptide of FIG. 25 (SEQ ID NO:50).
Plasmid pantiIL-8.2 having ATCC Accession No. 97056.
Plasmid p6G425chim2 having ATCC Accession No. 97055.
Chimeric fab encoded by p6G425chim2 having ATCC Accession No. 97055.
An antibody fragment selected from the group consisting of Fab, Fab', Fab'-SH, Fv, and F(ab').sub.2, wherein the antibody fragment comprises the complementarity determining regions of the light chain polypeptide of FIG. 24 (SEQ ID NO:48) and the complementarity determining regions of the heavy chain polypeptide FIG. 25 (SEQ ID NO:50).
Dependencies are inferred from the claim text.