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AssigneesICOS Corporation, Vanderbilt University, The Board of Regents of the University of Washington
InventorsJoseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
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The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
A fragment of human cGMP-binding phosphodiesterase consisting of the amino acids 516 to 875 of SEQ ID NO:
A fragment of human cGMP-binding phosphodiesterase consisting of the amino acids 1-494 of SEQ ID NO:
A fragment of human cGMP-binding phosphodiesterase consisting of the amino acids 1-549 of SEQ ID NO:
Dependencies are inferred from the claim text.