Diagnostic test composition
AssigneeChek-Med Systems, Inc.
InventorRobert G. Whalen
Life of this patent
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Abstract
The present invention relates to an improved test composition for the diagnosis of gastric ulcers, duodenal ulcers, gastritis, gastric lymphoma and gastric carcinoma by the detection of the bacteria Helicobacter pylori and the enzyme catalase associated with such conditions. The new test composition differs from the prior art agar compositions in being an aqueous solution containing hydrogen peroxide, urea, monobasic sodium phosphate and bromthymol blue as an indicator, and in being far more rapid than the prior art test compositions.
Claims6
An improved test composition for detecting Helicobacter pylori in a specimen comprising by weight:
- a) an aqueous solution containing about 0.5% to about 6% hydrogen peroxide;
- b) about 0.5% to about 2.0% urea;
- c) about 0.001% to about 0.01% monobasic sodium phosphate;
- d) about 0.01% to about 0.1% bromthymol blue indicator;
- and
- the remaining percent is water.
A test composition comprising a) an aqueous solution containing about 0.5% to about 6.0% hydrogen peroxide;
- b) about 0.5% to about 2.0% urea;
- c) about 0.001% to about 0.01% monobasic sodium phosphate;
- d) about 0.01% to about 0.1% bromthymol blue indicator;
- and the remaining percent is water that exploits the presence of catalase in a microorganism test specimen and/or a biopsy test specimen to expedite the decomposition of urea by the urease enzyme.
Dependencies are inferred from the claim text.