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US 5,702,897 AGranted
Interaction of proteins involved in a cell death pathway
AssigneeThe Burnham Institute
InventorsJohn C. Reed, Takaaki Sato
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Abstract
The present invention provides methods for detecting an interaction among proteins involved in regulating cell death. The invention also provides a drug screening assay useful for identifying agents that alter an interaction among proteins involved in controlling cell death. The invention further provides a method for identifying novel proteins that are involved in a cell death pathway.
Claims5
A method of detecting a protein involved in a cell death pathway, comprising the steps of:
- a. obtaining a cell that expresses an exogenous protein involved in a cell death pathway, wherein expression of said exogenous protein results in the death of said cell;
- b. expressing in said cell a second protein that is suspected of being involved in a cell death pathway;
- and
- c. detecting the survival of said cell, wherein said survival indicates that said second protein is involved in a cell death pathway.
1 more element
Dependencies are inferred from the claim text.