Back to results
US 5,702,727 AGranted
Compositions and methods for the oral delivery of active agents
AssigneeAlza Corporation
InventorsAlfred A. Amkraut, Heechung Yang
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeAlza Corporation
InventorsAlfred A. Amkraut, Heechung Yang
Estimating the term…
Compositions and methods for the oral administration of drugs and other active agents are provided. The compositions comprise an active agent carrier particle attached to a binding moiety which binds specifically to a target molecule present on the surface of a mammalian enterocyte. The binding moiety binds to the target molecule with a binding affinity or avidity sufficient to initiate endocytosis or phagocytosis of the particulate active agent carrier so that the carrier will be absorbed by the enterocyte. The active agent will then be released from the carrier to the host's systemic circulation. In this way, degradation of degradation-sensitive drugs, such as polypeptides, in the intestines can be avoided while absorption of proteins and polypeptides from the intestinal tract is increased.
A method for systemically delivering a protein or polypeptide drug to a mammalian host, said method comprising (a) orally administering to the host a composition which comprises the protein or polypeptide drug protectively retained by a carrier particle wherein said carrier particle is attached to a binding moiety which binds specifically to a target molecule present on the surface of a mammalian enterocyte, the target molecule being an endocytosis- or phagocytosis- promoting receptor, and (b) delivering the protein or polypeptide drug through the intestinal mucosa of the host to the blood stream of the host, wherein the carrier particle is absorbed by the mammalian enterocyte prior to release of the protein or polypeptide drug from the particle.
Dependencies are inferred from the claim text.