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US 5,702,720 AGranted
Transdermal device for the delivery of flurbiprofen
AssigneeMinnesota Mining and Manufacturing Company
InventorsJochem Effing, Eberhard Gruhlke, Kristin Godbey, Wolfgang Welsing
Life of this patent
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Abstract
A transdermal drag delivery device involving an acrylate or methacrylate based copolymer, a skin penetration enhancer, a polyvinylpyrrolidone polymer, and a therapeutically effective amount of flurbiprofen.
Claims18
A transdermal delivery device comprising:
- (A) a backing;
- (B) an adhesive layer adhered to one surface of the backing and consisting essentially of a mixture of
- (1) a copolymer comprising interpolymerized units derived from
- (a) one or more A monomers selected from the group consisting of alkyl acrylates containing 4 to 10 carbon atoms in the alkyl group and alkyl methacrylates coming 4 to 10 carbon atoms in the alkyl group;
- and
- (b) one or more ethylenically unsaturated B monomers comprising a functional group selected from the group consisting of carboxylic acid, sulfonamide, urea, carbamate, carboxamide, hydroxy, amino, oxy, oxo and cyano;
- (2) flurbiprofen in a therapeutically effective amount;
- (3) isopropyl myristate in an amount of about 20 to about 40 percent by weight based on the total weight of the adhesive layer, and
- (4) a polyvinylpyrrolidone in an amount of about 1 to about 10 percent by weight based on the total weight of the adhesive layer, wherein the device has a moisture vapor transmission rate greater than 400 g/m.sup.2 /24 hr.
6 more elements
A transdermal delivery device comprising:
- (A) a backing comprising a nonwoven polypropylene web having multidirectional stretch;
- (B) an adhesive layer adhered to one surface of the backing and consisting essentially of a homogeneous mixture of
- (1) a copolymer comprising
- (a) about 84 to 94 percent by weight of interpolymerized units derived from alkyl acrylates containing 4 to 10 carbon atoms in the alkyl group, and
- (b) about 6 to 16 percent by weight of interpolymerized units derived from monomers selected from the group consisting of acrylic acid, acrylamide and dimethylacrylamide;
- (2) 5 to 15 percent by weight of S(+)-flurbiprofen based on the total weight of the adhesive layer;
- (3) isopropyl myristate in an amount of about 25 to about 35 percent by weight based on the total weight of the adhesive layer;
- and
- (4) a polyvinylpyrrolidone in an amount of about 3 to about 8 percent by weight based on the total weight of the adhesive layer, wherein the device has a moisture vapor transmission rate greater than 400 g/m.sup.2 /24 hr.
6 more elements
Dependencies are inferred from the claim text.