Reinforced biological sealants
AssigneeDrying Technology
InventorsVictor V. Nikolaychik, Brent A. Burdick, Leonid V. Nikolaychik
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Abstract
A reinforced biological sealant is disclosed. The sealant includes a fibrinogen composition adapted to be applied to a wound, and a solid thrombin composition layered on the fibrinogen film. At least one of the fibrinogen or thrombin compositions comprises a reinforcement filler. Means are provided for activating formation of a fibrin mesh from the fibrinogen and thrombin compositions, thereby effecting hermetization and hemostasis of the wound.
Claims15
A reinforced, prefabricated biological sealant, the sealant comprising:
- a) a fibrinogen composition adapted to be applied to a treatment condition, and
- b) a thrombin composition layered on the fibrinogen composition,
- wherein at least one of the fibrinogen or thrombin composition comprises a reinforcement filler so that the sealant comprises a reinforcement filler, wherein the sealant has a critical pressure of at least 150 mm Hg at two minutes, and wherein the sealant is a solid film.
A reinforced, prefabricated biological sealant, the sealant comprising:
- a) a fibrinogen composition adapted to be applied to a treatment condition, and
- b) a thrombin composition layered on the fibrinogen composition,
- wherein at least one of the fibrinogen or thrombin composition comprises a reinforcement filler so that the sealant comprises a reinforcement filler, wherein the sealant has a critical pressure of at least 150 mm Hg at two minutes, wherein the sealant is a solid film, and wherein the fibrinogen and thrombin compositions are dried for 5 to 24 hours at temperatures in the range of 10.degree. C. to 50.degree. C., at a pressure in the range of 25 Torr to 300 Torr.
Dependencies are inferred from the claim text.