Antibody methods for the treatment of a hormone-mediated disease
AssigneeChiron Corporation
InventorsMichael Kriegler, Carl Perez
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Abstract
Cleavage site blocking antibody that binds to prohormones, preferable Tumor Necrosis Factor, thereby preventing the formation of prohormone fragment(s) by proteolysis of the prohormone, and uses of the antibody including prophylactic and therapeutic methods to treat disease, and diagnostic assays for determining the amount of the prohormone and prohormone fragments present in a patients body.
Claims8
A method for prophylactically or therapeutically treating a patient for a disease caused by the presence of a mature hormone in said patient, said mature hormone comprising a 15 kd or a 17 kd TNF and being produced by the protease cleavage of a prohormone form of said mature hormone, said prohormone form comprising a 26 kd TNF, said cleavage being at a prohormone cleavage site, said method comprising administering said patient an effective amount of a monoclonal antibody or an antigen binding fragment thereof that binds to said prohormone TNF at said cleavage site to sterically hinder access of said protease to said cleavage site, thereby preventing or inhibiting formation of said mature hormone TNF.
Dependencies are inferred from the claim text.