Method to detect bone and other connective tissue disorders in humans and animals
AssigneeRowett Research Institute
InventorSimon Peter Robins
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Abstract
The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen-derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.
Claims26
A method to monitor or diagnose the presence of a disorder associated with a connective tissue metabolism abnormality, which method comprises
- comparing the level of native free crosslinks derived from collagen in a non-hydrolyzed biological fluid of a human subject with the level of said crosslinks in normal subjects so as to diagnose a subject having an enhanced level of said crosslinks as showing the presence of said disorder,
- wherein said crosslinks are selected from native peptide free non-glycosylated pyridinoline (N-Pyd), native peptide-free deoxypyridinoline (N-Dpd), or the sum of N-Pyd and N-Dpd.
Dependencies are inferred from the claim text.