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US 5,700,690 AGranted
Compositions and methods for inhibiting fibrogenesis
AssigneeThe Trustees of the University of Pennsylvania
InventorsEric G. Neilson, Theodore Danoff, Hirokazu Okada, Frank Strutz
Life of this patent
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Abstract
Vectors, or naked DNA, containing a promoter for an FSP1 gene and a downstream gene capable of attenuating fibroblasts and their function are provided. Methods of using these vectors to inhibit tissue injury related to fibrogenesis are also provided.
Claims6
A vector comprising an FSP1 gene promoter sequence contained in Seq. ID No. 1 operably linked to a DNA sequence of interest, wherein said promoter sequence directs transcription of said DNA sequence of interest in mammalian fibroblasts.
Dependencies are inferred from the claim text.