Lipid vesicles having a bilayer containing a surfactant with anti-viral and spermicidal activity
AssigneeNovavax, Inc.
InventorD. Craig Wright
Life of this patent
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Abstract
A novel formulation having anti-viral and spermicidal properties has been developed. The formulation contains lipid vesicles having an outer bilayer formed of a non-ionic amphiphile, a surfactant such as having spermicidal and/or anti-viral activity, an oil and a sterol. The selection of the components making the vesicle is such that the formulation provides rapid spermicidal or anti-viral activity. The formulation and methods of the invention are particularly useful in the mucous membranes such as the vaginal tract and has been tested against viruses such as HIV and Vaccinia.
Claims61
A method of inactivating spermatozoa comprising the step of exposing said spermatozoa to a latex-compatible lipid vesicle formulation having topical spermicidal activity;
- said lipid vesicle formulation containing lipid vesicles having an outer bilayer wherein, said lipid vesicles include a non-ionic amphiphile, an oil, a sterol, and a spermicidal surfactant, wherein said lipid vesicles are formed primarily of said non-ionic amphiphile, wherein said non-ionic amphiphile, said oil and said spermicidal surfactant are selected such that said spermicidal surfactant is not dissolvable in said oil and at least a portion of said spermicidal surfactant is in the outer bilayer of said lipid vesicle.
A method of inactivating an enveloped virus comprising the step of exposing said enveloped virus to a latex-compatible lipid vesicle formulation, said lipid vesicle formulation containing lipid vesicles having an outer bilayer wherein, said lipid vesicles include a non-ionic amphiphile, an oil, a sterol, and a nonoxyphenol surfactant, wherein said lipid vesicles are formed primarily of said non-ionic amphiphile, wherein said non-ionic amphiphile, said oil and said nonoxyphenol surfactant are selected such that said nonoxyphenol surfactant is not dissolvable in said oil and at least a portion of said nonoxyphenol surfactant is in the outer bilayer of said lipid vesicle.
A method of inactivating spermatozoa comprising the step of exposing said spermatozoa to a latex-compatible lipid vesicle formulation, said lipid vesicle formulation containing lipid vesicles having an outer bilayer, wherein said lipid vesicles include a non-ionic amphiphile, an oil, a sterol, and a nonoxyphenol surfactant, wherein said lipid vesicles are formed primarily of said non-ionic amphiphile, wherein said non-ionic amphiphile, said oil and said nonoxyphenol surfactant are selected such that said nonoxyphenol surfactant is not dissolvable in said oil and at least a portion of said nonoxyphenol surfactant is in the outer bilayer of said lipid vesicle.
A formulation for inactivating spermatozoa or enveloped viruses comprising a latex-compatible lipid vesicle formulation, wherein said lipid vesicle formulation includes lipid vesicles, wherein said vesicles include a non-ionic amphiphile, an oil, a sterol, and a nonoxyphenol surfactant, wherein said lipid vesicles are formed primarily of said non-ionic amphiphile, wherein said non-ionic amphiphile, said oil and said nonoxyphenol surfactant are selected such that said nonoxyphenol surfactant is not dissolvable in said oil and at least a portion of said nonoxyphenol surfactant is in the outer bilayer of said lipid vesicle.
Dependencies are inferred from the claim text.