Process for the production of arabinonucleotides
AssigneeSchering Corporation
InventorsHeidi Hummel-Marquardt, Thomas Schmitz, Mario Kennecke, Alfred Weber
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Abstract
A process for the production of arabinonucleotides of general formula I ##STR1## in which X represents a hydrogen atom or a fluorine atom, is described, which is characterized in that an arabinonucleoside of general formula II ##STR2## in which X has the above-mentioned meaning, is fermented in the presence of an aryl phosphate of general formula III ##STR3## in which Y symbolizes a hydrogen atom or a nitro group and Z symbolizes two hydrogen atoms or two alkali metal atoms, with a microorganism that is capable of phosphorylating nucleosides.
Claims5
A process for the production of an arabinonucleotide of formula I ##STR7## wherein:
- X is a hydrogen atom or a fluorine atom, comprising, fermenting an arabinonucleoside of formula II ##STR8## wherein X has the above-mentioned meaning, in the presence of an aryl phosphate of formula III ##STR9## where Y is a hydrogen atom or a nitro group;
- and
- Z is two hydrogen atoms or two alkali metal atoms, with a microorganisms that is capable of phosphorylating nucleosides.
Dependencies are inferred from the claim text.