Diagnostic method, test kit, drug and therapeutic treatment for autoimmune diseases
OwnerEeva-Marjatta Saloneninventor
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Abstract
Synthesized telomeric sequences bind to and can be used for detecting anti-DNA antibodies in serum. Autoimmune diseases such as Lupus Erythematosus, Rheumatoid Arthritis, and Scleroderma, can be detected by detecting an elevated level of anti-DNA antibodies using telomeric sequences. Test kits for such detection are provided including immobilized telomeric sequences capable of binding anti-DNA antibodies. Pharmaceutical compositions for inhibiting or reducing the activity of anti-DNA antibodies contain an effective amount of telomeric sequences effective in inhibiting the antibodies specific to the patient treated.
Claims26
A method for detecting anti-DNA-antibodies in a sample by contacting said sample with a telomeric sequence of DNA selected from the group consisting of a single stranded telomere, a complementary strand thereto, a double stranded teleomere, and a part or a repeat or a combination of any of the foregoing, to provide binding of said antibodies to said telomeric sequence of DNA, and detecting said binding of said antibodies to said telomeric sequence.
The method according 4, wherein the serum is human serum.
A diagnostic method for detecting autoimmune diseases in mammals by contacting a serum sample from said mammal with telomeric sequence of DNA which is specific to said mammal and which is selected from the group consisting of a single stranded telomere, a complementary strand thereto, a double stranded telomere, a part or a repeat or a combination of any of the foregoing, to detect an elevated level of autoantibodies present in said mammals above a normal level of autoantibodies.
A test kit for the diagnosis of autoimmune disease in mammals, said test kit including a telomeric sequence of DNA selected from the group consisting of a single stranded telomere, a complementary strand thereto, a double stranded telomere, a part or a repeat or a combination of any of the foregoing, capable of binding autoantibodies present in said serum, wherein said telomeric sequence is immobilized on a solid support and
- a label capable of indicating the binding of said autoantibody to said telomeric sequence.
A test kit for the diagnosis of autoimmune disease in mammals, said test kit including a telomeric sequence of DNA selected from the group consisting of a dingle stranded telomere, a complementary strand thereto, a double stranded telomere, a part or a repeat or a combination of any of the foregoing, capable of binding autoantibodies present in said serum;
- and
- an amount of one or more labelled anti-Ig-antibodies selected from the group consisting of anti-IgG, anti-IgM, anti-IgA, anti-IgD and anti-IgE.
Dependencies are inferred from the claim text.