Nutritional formula with ribo-nucleotides

An infant formula, said formula comprising:

• 1) protein, said protein being of a concentration of between 10 and 35 grams per liter of formula;
• 2) fat, said fat being of a concentration of between 20 and 45 grams per liter of formula;
• 3) carbohydrates, said carbohydrates including those from total dietary fiber being of a concentration of between 60 and 110 grams per liter of formula;
• and
• 4) at least 70 mg of nucleotide equivalents per liter of formula and said nucleotide equivalents are selected from the group consisting of RNA;
• mono-, di- and triphosphate esters of adenosine, cytidine, guanosine and uridine;
• and wherein the weight ratio of said cytidine nucleotide equivalents to said uridine nucleotide equivalents is from about 1.5:1 to about 2.6:1;
• of said cytidine nucleotide equivalents to said adenosine nucleotide equivalents is from about 2:1 to about 3.9:1;
• and of cytidine nucleotide equivalents to said guanosine equivalents is from about 1.75:1 to about 2.8:1.

A method of improving the immune response sensitivity of the immune system of a human, wherein said method comprises feeding a human in need of treatment a formula, the improvement comprising feeding said human a formula consisting essentially of:

• 1) protein, said protein being of a concentration of between 10 and 35 grams per liter of formula;
• 2) fat, said fat being of a concentration of between 20 and 45 grams per liter of formula;
• 3) carbohydrates, said carbohydrates being of a concentration of between 60 and 110 grams per liter of formula;
• and
• 4) at least 70 mg of nucleotide equivalents per liter of formula, and wherein said nucleotide equivalents are nucleotide equivalents of each of adenosine, cytidine, guanosine and uridine;
• and wherein the weight ratio of CMP:UMP is from about 1.5:1 to about 2.6:1;
• of CMP:AMP is from about 2:1 to about 3.9:1;
• and of CMP:GMP is from about 1.75:1 to about 2.8:1.

A method of improving the immune response sensitivity of the immune system of a human infant, said method comprising feeding a human infant in need of treatment a nutritional formula, the improvement comprising feeding a human infant a nutritionally complete formula comprising:

• 1) protein;
• 2) fat;
• 3) carbohydrates;
• and
• 4) at least 70 mg nucleotide equivalents per liter of formula, said nucleotides comprising the monophosphate esters of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is from about 1.5:1 to about 2.6:1;
• of CMP:AMP is from about 2:1 to about 3.9:1;
• and of CMP:GMP is from about 1.75:1 to about 2.8:1.

A method of improving the immune response sensitivity of the immune system of a human infant to an antigen, said method comprising feeding a human infant in need of treatment a nutritional formula, the improvement comprising feeding said human infant an infant formula that contains:

• 29-39 mg of CMP per liter of formula;
• 15-21 mg of UMP per liter of formula;
• 10-16 mg of AMP per liter of formula and 14-20 mg of GMP per liter of formula or their nucleotide equivalents and wherein the weight ratio of CMP:UMP is from about 1.5:1 to about 2.6:1;
• of CMP:AMP is from about 2:1 to about 3.9:1;
• and of CMP:GMP is from about 1.75:1 to about 2.8:1.

An enteral formula comprising per 100 Kcal of formula:

• a) from about 1.5 to about 5 grams of protein;
• b) from about 3 to about 6.5 grams of fat;
• c) from about 8.7 to about 16 grams of carbohydrate;
• and
• d) about 10 milligrams of nucleotide equivalents, wherein the nucleotide equivalents are nucleotide equivalents of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising per 100 Kcal of formula:

• a) from about 1.5 to about 5 grams of protein;
• b) from about 3 to about 6.5 grams of fat;
• c) from about 8.7 to about 16 grams of carbohydrate;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

A nutritionally complete infant formula comprising:

• protein;
• fat;
• carbohydrate;
• and nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:
• 1 and wherein the level of nucleotide equivalents is about 10 milligrams per 100 Kcal of formula.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) from about 2 to about 7 mg of nucleotide equivalents per gram of protein, wherein the nucleotide equivalents are adenosine, cytidine, guanosine and uridine nucleotide equivalents and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1 the weight.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) from about 1.5 to about 3.5 mg of nucleotide equivalents per gram of fat, wherein the nucleotide equivalents are adenosine, cytidine, guanosine and uridine nucleotide equivalents and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) from about 0.6 to about 1.2 mg of nucleotide equivalents per gram of carbohydrate, wherein the nucleotide equivalents are adenosine, cytidine, guanosine and uridine nucleotide equivalents and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the level of cytidine equivalent is from about 0.8 to about 4 mg of CMP per gram of protein and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the level of cytidine equivalent is from about 0.6 to about 1.9 mg of CMP per gram of fat and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the level of cytidine equivalent is from about 0.2 to about 0.7 mg of CMP per gram of carbohydrate and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the level of cytidine equivalent is about 2 mg of CMP per 100 Kcal of formula and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising per 100 Kcal of formula:

• a) from about 1.5 to about 5 grams of protein;
• b) from about 3 to about 6.5 grams of fat;
• c) from about 8.7 to about 16 grams of carbohydrate;
• and
• d) from about 1.5 to about 15 milligrams of nucleotide equivalents, wherein the nucleotide equivalents are nucleotide equivalents of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the level of adenosine equivalent is about 1 mg of AMP per 100 Kcal of formula and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising:

• a) from about 1.5 to about 5 grams of non-fat milk protein per 100 Kcal of formula;
• b) from about 3 to about 6.5 grams of fat per 100 Kcal of formula;
• c) from about 8.7 to about 16 grams of carbohydrate per 100 Kcal of formula;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine, wherein the level of cytidine equivalent is from about 0.8 to about 4 mg of CMP per gram of non-fat milk protein and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula comprising per liter of formula:

• a) from about 10 to about 35 grams of protein;
• b) from about 20 to about 45 grams of fat;
• c) from about 60 to about 110 grams of carbohydrate;
• and
• d) about 40 milligrams of nucleotide equivalents, wherein the nucleotide equivalents are nucleotide equivalents of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is greater than about 1.5:1, the weight ratio of CMP:AMP is greater than about 2:1 and the weight ratio of CMP:GMP is greater than about 1.75:1.

An enteral formula supplemented with nucleotide mono-phosphates, comprising per 100 Kcal of formula:

• a) from about 1.5 to about 5 grams of protein;
• b) from about 3 to about 6.5 grams of fat;
• c) from about 8.7 to about 16 grams of carbohydrate;
• and
• d) nucleotide equivalents of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is from about 1.5:1 to about 2.6:1, the weight ratio of CMP:AMP is from about 2:1 to about 3.9:1, and the weight ratio of CMP:GMP is from about 1.75:1 to about 2.8:1.

An enteral formula supplemented with nucleotide mono-phosphates, comprising per 100 Kcal of formula:

• a) from about 1.5 to about 5 grams of protein;
• b) from about 3 to about 6.5 grams of fat;
• c) from about 8.7 to about 16 grams of carbohydrate;
• and
• d) from about 1.5 to about 15 milligrams of nucleotide equivalents, wherein the nucleotide equivalents are nucleotide equivalents of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP:UMP is from about 1.5:1 to about 2.6:1, the weight ratio of CMP:AMP is from about 2:1 to about 3.9:1, and the weight ratio of CMP:GMP is from about 1.75:1 to about 2.8:1.