Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions
AssigneeVectorpharma International S.p.A.
InventorsTiziana Canal, Mara Lucia Lovrecich, Fabio Carli
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Abstract
Pharmaceutical compositions in the form of particles comprising a biodegradable polymer and/or a polysaccharide jellifying and/or bioadhesive polymer, an amphiphilic polymer, an agent modifying the interface properties of the particles and a pharmacologically active substance. Said compositions exhibit improved biocompatibility features and allow a controlled release of the active substance.
Claims20
Process for the preparation of pharmaceutical compositions in the form of particles suitable for the controlled release of a pharmaceutically active substance comprising a biodegradable polymer, an amphiphilic polymer, an agent modifying the interface properties at a concentration between 0.1 and 99.9% and a pharmaceutically active substance at a concentration between 0.01 and 99.9% wherein:
- (a) the biodegradable polymer and amphiphilic polymer and the agent modifying the interface properties are co-solubilized in the presence or absence of solvents to form a mixture;
- (b) the pharmaceutically active substance is dissolved or dispersed in the mixture;
- (c) the obtained mixture is brought in the from of particles having diameter comprised between 0.1 and 150 .mu.m by means of emulsifying or extruding or spray-drying or spray-congealing techniques;
- (d) said particles are optionally washed and dried according to classical methods.
Dependencies are inferred from the claim text.