US 5,698,213 AGranted

Hydrogels of absorbable polyoxaesters

AssigneeEthicon, Inc.

InventorsDennis D. Jamiolkowski, Rao S. Bezwada

Life of this patent

Estimating the term…

Loading patent…

Abstract

The present invention describes a new crossslinkable and crosslinked aliphatic polyoxaesters and blends thereof that may be used to produce hydrogels, surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The crosslinked aliphatic polyoxaesters of the present invention are formed from an aliphatic polyoxaester a first divalent repeating unit of formula I: O--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! I and a second repeating unit selected from the group of formulas consisting of: --O--R.sub.4 --!.sub.A, II --O--R.sub.5 --C(O)--!.sub.B, III and (--O--R.sub.5 --C(O)!.sub.P --O--).sub.L G XI and combinations thereof. These aliphatic polyoxaesters may be blended with other polymers which are preferably biocompatible.

Claims11

Dependent claims

A crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:

O--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O--).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200.

17 more elements

A polymer blend comprising a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:

O--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O--).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200;
wherein the polyoxaester is crosslinked;
and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.

20 more elements

A device containing a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:

O--C(O)--C(R.sub.1)(R.sub.2) --O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O--).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200.

17 more elements

A device containing a polymer blend of a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:

O--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O--).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.3 --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200;
and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.

19 more elements

A coated device comprising a device coated with a crosslinked formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:

O--C(O)--C (R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200.

17 more elements

A coated device comprising a device coated with a polymer blend of a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:

O--C(O)--C (R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200;
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate) and combinations thereof wherein the inherent viscosity of the polymer blend is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25.degree. C.

18 more elements

A drug delivery matrix comprising a drug and a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:

O--C(O)--C (R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200.

17 more elements

A drug delivery matrix comprising a drug and a polymer blend containing a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:

O--C(O)--C (R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200;
and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate) and combinations thereof.

19 more elements

A hydrogel comprising water and a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:

O--C(O)--C (R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200.

17 more elements

A prepolymer comprising an aliphatic polyoxaester having a first divalent repeating unit of formula I:

O--C(O)--C (R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
--O--R.sub.4 --!.sub.A, II
--O--R.sub.5 --C(O)--!.sub.B, III
and
(--O--R.sub.5 --C(O)!.sub.P --O).sub.L G XI
and combinations thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R.sub.3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
--(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R.sub.4 is an alkylene unit containing from.2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R.sub.5 is selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --O--C(O)-- and --(CH.sub.2).sub.F --C(O)--CH.sub.2 --;
R.sub.6 and R.sub.7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R.sub.8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups;
and L is an integer from about 1 to about 200;
wherein the polyoxaester is covalently linked to a polymerizable region.

18 more elements

Dependencies are inferred from the claim text.

Facts

Application: 08/744,289Filed 6 Nov 1996 · continuation in part
Priority: 6 Mar 1995
Granted: 16 Dec 1997
Term ends: Not estimatedThe source records don’t support an estimate.

Classification44 codes

A61F 2/20
Prostheses implantable into the body: larynxes; Tracheae combined with larynxes or for use therewith
A61K 9/204
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers:…
A61L 15/225
Containing macromolecular materials: mixtures of macromolecular compounds
A61L 15/26
Containing macromolecular materials: macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated…

Family

Serial399,308Parent of this continuation-in-part · filed 6 Mar 1995
Serial554,614Parent of this continuation-in-part · filed 6 Nov 1995
Serial611,119Parent of this continuation-in-part · filed 5 Mar 1996
US 5,607,687 AParent of this continuation-in-part
US 5,464,929 AParent of this continuation-in-part
US 5,698,213 AThis patent

From the US filing history. Foreign family members aren’t listed.