Primary and secondary immunization with different physio-chemical forms of antigen
AssigneeConnaught Laboratories Limited
InventorsRobert S. Becker, Laura Ferguson, Lorne Erdile, Maurice W. Harmon, Robert Huebner
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Abstract
Animals, including humans, are immunized by antigens, for example, the HA antigen of influenza, by first administering to a naive animal a normally strongly-immunogenic form of the antigen, for example, inactiviated or attenuated whole cell virus and subsequently administering a normally weakly-immunogenic isolated and purified viral antigen, to achieve an enhanced immune response to the purified viral antigen.
Claims10
A method of achieving an immune reaction to a highly-immunogenic form of a viral bacterial antigen in an animal, which consists essentially of the steps in the sequence set forth:
- administering by vaccination to said animal the highly-immunogenic form of said antigen to achieve a primary immune reaction to the antigen, wherein the highly-immunogenic form of said antigen is particulate, and
- subsequently administering by vaccination to said animal a form of said antigen which is weakly-immunogenic and capable of recalling the memory immune reaction to the highly-immunogenic form of the antigen, to achieve a booster immune reaction to the antigen, wherein said weakly-immunogenic form of said antigen is soluble.
Dependencies are inferred from the claim text.