.beta.-phenylisoserine-(2R,3S), salts, preparation and use thereof
AssigneeRhone-Poulenc Rorer S.A.
InventorsJean-Pierre Duchesne, Max Ferraro
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Abstract
.beta.-phenylisiserine-(2R,3S), salts and preparation thereof through the action of ammonia on .beta.-phenylglycidic-(2R,3R) acid and its use in the preparation of taxane derivatives of general formula: ##STR1## wherein R is hydrogen or --COCH.sub.3 ;and R.sub.1 is phenyl or --O--C(CH.sub.3).sub.3.
Claims10
(2R,3S)-.beta.-Phenylisoserine or a salt thereof selected from alkali metal salts, alkaline earth metal salts and salts with nitrogenous bases.
Process for preparing (2R,3S)-.beta.-phenylisoserine, optionally in salt form, comprising reacting ammonia with (2R,3R)-.beta.-phenylglycidic acid or one of its salts, and isolating (2R,3S)-.beta.-phenylisoserine optionally in salt form.
Process for preparing (2R,3S)-.beta.-phenylisoserine, optionally in salt form, comprising:
- reacting ammonia with (2R,3R)-.beta.-phenylglycidic acid or one of its salts at a temperature of between 0.degree. to 100.degree. C.;
- said reaction being performed in the presence of an ammonium salt, and with from 10 to 100 moles of ammonia being used per mole of (2R,3R)-.beta.-phenylglycidic acid or one of its salts;
- and
- isolating (2R,3S)-.beta.-phenylisoserine optionally in salt form.
Dependencies are inferred from the claim text.