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US 5,684,145 AGranted
Carrier system against GNRH
AssigneeAkzo Nobel N.V.
InventorsAnna Van Der Zee, Irma Marianne Van Die, Willem Pieter Martin Hoekstra, Josephus Theodorus Gielen
Life of this patent
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Abstract
The present invention is concerned with vaccination of mammals against GnRH. The vaccine comprises a GnRH peptide conjugate to E. coli fimbrial-filaments and elicits an immune response against GnRH.
Claims8
A recombinant DNA molecule that codes for a hybrid protein, said hybrid protein comprising:
- an E. coli P-fimbrial filament that contains a major subunit thereof;
- and an antigenic determinant of GnRH or an analog or derivative of GnRH, which is inserted in hypervariable region 4 (HR4) of the major subunit, wherein said major subunit further comprises a mutation consisting of the creation of a StuI site in hypervariable region 1.
Dependencies are inferred from the claim text.