Coronary vasculature treatment method
AssigneeCormedics Corp.
InventorsStephen R. Igo, James W. Meador
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Abstract
Method and apparatus for treating blood vessels in a mammal, particularly humans, especially coronary blood vessels, for vascular thrombosis and angioplasty restenosis, thereby to decrease incidence of vessel rethrombosis, unstable angina and myocardial infarction, by administering a conager of an endothelium-derived bioactive agent, especially a nitrovasodilator, including one or more of nitric oxide or a nitric oxide donor agent, such as sodium nitroprusside and nitroglycerin, to an extravascular treatment site at a therapeutically effective dosage rate.
Claims21
The method of treating a mammal comprising the steps of:
- (a) selecting a congener of an endothelium-derived bioactive agent;
- (b) administering a therapeutically effective dosage of the selected congener to a site proximately adjacent the exterior of a coronary blood vessel;
- and
- (c) allowing the congener to treat the coronary blood vessel from the outside-in.
A method of treating a coronary blood vessel in a mammal, which comprises intrapericardially or transpericardially supplying sodium nitroprusside to the blood vessel in a therapeutically effective dose.
A method of treating a coronary blood vessel in a mammal, which comprises intrapericardially or transpericardially extravascularly delivering a congener of an endothelium-derived bioactive agent of said blood vessel at a therapeutically effective dosage rate.
Dependencies are inferred from the claim text.