Use of amidoamines in ophthalmic compositions
AssigneeAlcon Laboratories, Inc.
InventorsNissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park
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Abstract
The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described. The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.
Claims24
A preserved pharmaceutical composition comprising an aqueous ophthalmic composition and 0.00001 to 0.05 wt. % of a compound of the following formula to preserve said ophthalmic composition from microbial contamination:
- ##STR2## wherein:
- R.sup.1 is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, or alkoxyaryl;
- n is 2 to 16;
- and
- R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof.
An ophthalmic composition for disinfecting contact lenses, comprising 0.00005 to 0.1 wt. % of a compound of the following formula:
- ##STR3## wherein:
- R.sup.1 is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, or alkoxyaryl;
- n is 2 to 16;
- and
- R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable vehicle therefor.
A method of disinfecting a contact lens which comprises immersing the lens in an antimicrobial composition for a time sufficient to disinfect the lens, said composition comprising 0.00005 to 0.1 wt. % of a compound of the following formula:
- ##STR4## wherein:
- R.sup.1 is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, or alkoxyaryl;
- n is 2 to 16;
- and
- R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable vehicle therefor.
A method of preserving an ophthalmic composition which comprises including in the composition 0.00001 to 0.05 wt. % of a compound of the following formula to preserve the composition from microbial contamination:
- ##STR5## wherein:
- R.sup.1 is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, or alkoxyaryl;
- n is 2 to 16;
- and
- R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof.
A method of cleaning a contact lens which comprises contacting the surfaces of the lens with a composition comprising an amount of a compound of the following formula effective to clean the lens:
- ##STR6## wherein:
- R.sup.1 is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, or alkoxyaryl;
- n is 2 to 16;
- and
- R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable vehicle thereof.
Dependencies are inferred from the claim text.