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US 5,578,709 AGranted
Macromolecular microparticles and methods of production
AssigneeMiddlesex Sciences, Inc.
InventorJames E. Woiszwillo
Life of this patent
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Abstract
A macromolecular microparticle composition formed by dehydrating an aqueous macromolecule solution and crosslinking the dehydrated macromolecules with a crosslinking agent while in a liquid phase or with heat. Preferably, the dehydrating agent is a polymer mixture of polyvinylpyrrolidone and polyethylene glycol, the crosslinking reagent is glutaraldehyde, and the macromolecule is a protein, most preferably an immunoglobulin. Methods of use for research, diagnostics and therapeutics are also provided.
Claims18
A method for making microparticles having uniform size comprising the steps of:
- a) combining a solution containing a macromolecule with a solution containing both polyvinylpyrrolidone and polyethylene glycol to produce a reaction solution:
- b) incubating the reaction solution at a predetermined temperature greater than room temperature for a sufficient amount of time to form microparticles;
- and
- c) separating the microparticles from the reaction solution.
1 more element
Microparticles prepared by the method of
- a) combining a solution containing a macromolecule with a solution containing both polyvinylpyrrolidone and polyethylene glycol to produce a reaction solution;
- b) incubating the reaction solution at a predetermined temperature greater than room temperature for a sufficient amount of time to form microparticles;
- and
- c) separating the microparticles from the reaction solution.
1 more element
Dependencies are inferred from the claim text.