Method of grinding pharmaceutical substances
AssigneeNano Systems L.L.C.
InventorsJoseph A. Bruno, Brian D. Doty, Evan Gustow, Kathleen J. Illig, Nats Rajagopalan, Pramod Sarpotdar
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Abstract
A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
Claims16
A method of preparing particles of a diagnostic imaging agent by grinding said agent with rigid grinding media to reduce said particles to submicron size, wherein said grinding media has a substantially spherical shape, has a particle size range of 0.1 to 3 mm and comprises a polymeric resin.
A method of preparing particles of a drug substance by grinding said substance with rigid grinding media to reduce said particles to submicron size, wherein said grinding media has a substantially spherical shape, has a particle size range of 0.1 to 3 mm and comprises a polymeric resin.
Dependencies are inferred from the claim text.