4-substituted pyrazoloquinoline derivatives
AssigneeSchering Corporation
InventorsAdriano Afonso, Joseph M. Kelly, Samuel Chackalamannil
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Abstract
The invention relates to compounds represented by formula 1a or 1b ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1, R.sub.2, R.sub.3, R.sub.8, R.sub.9, and n are as described herein. These compounds are useful as agents in treating herpes virus infections.
Claims12
A compound represented by formula 2 ##STR72## and pharmaceutically acceptable salts thereof wherein R.sub.1 equals H, (C.sub.2 -C.sub.8)alkanoyl, ##STR73## or -CH.sub.2 O-(C.sub.2 -C.sub.8)alkanoyl R.sub.2 is H, (C.sub.1 -C.sub.8)alkyl, (C.sub.2 -C.sub.8)alkanoyl, -(C.sub.2 -C.sub.6)alkylene, -(CHR.sub.4).sub.S -N(R.sub.5).sub.2, -(CHR.sub.4).sub.S -CO.sub.2 M, ##STR74## R.sub.3 is OR.sub.5, F, Cl, Br, I, CF.sub.3 or, (C.sub.1 -C.sub.8)alkyl;
- R.sub.4 is H or (C.sub.1 -C.sub.8)alkyl;
- R.sub.5 is H, (C.sub.1 -C.sub.8)alkyl or (C.sub.2 -C.sub.8)alkanoyl;
- R.sub.6 is R.sub.3, N(R.sub.5).sub.2, (C.sub.2 -C.sub.7)alkanoyl or H;
- R.sub.9 is (C.sub.1 -C.sub.8)alkyl;
- M is H or a pharmaceutically acceptable cation;
- q is 2 or 3;
- s is 1, 2, 3, or 4;
- and
- t is 0, 1, 2, or 3;
- and
- when R.sub.1 is H, R.sub.3 is not methyl.
A compound of the formula ##STR80## wherein R.sub.50 is the residue of a naturally occuring .alpha.-amino acid, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.