Controlled release powder and process for its preparation
AssigneeElan Corporation, plc
InventorsRandall T. Sparks, Edward J. Geoghegan
Life of this patent
Estimating the term…
Abstract
A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 .mu.m. Each of the micro-particles is in the form of a micromatrix of an active ingredient uniformly distributed in at least one non-toxic polymer. The micro-particles have a predetermined release of active ingredient when the dissolution rate thereof is measured according to the Paddle Method of U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m.
Claims12
A pharmaceutical suspension of controlled release microparticles for oral administration, comprising:
- discrete microparticles containing active ingredient in intimate admixture with at least one non-toxic polymer, each of said microparticles being in the form of a micromatrix with the active ingredient uniformly distributed therethrough but not entirely coated by polymer, said particles having an average size of from 0.1 to 125 .mu.m, and an aqueous vehicle for suspending said microparticles comprising a substance for inhibiting the release of active ingredient from the microparticles when said microparticles are stored in said vehicle.
A pharmaceutical suspension of controlled release microparticles for oral administration, comprising:
- discreet microparticles containing active ingredient and intimate admixture with at least one non-toxic polymer, each of said microparticles being in the form of a micromatrix with the active ingredient uniformly distributed therethrough but not entirely coated by polymer, said particles having an average size of from 0.1 to 1.25 microns, and an aqueous vehicle for suspending said microparticles comprising a substance for inhibiting the release of active ingredient selected from the group consisting of sorbitol and sugar, said substance inhibiting the release of active ingredient from the microparticles when said microparticles are stored in said vehicle.
A pharmaceutical suspension of controlled release microparticles containing theophylline in intimate admixture with at least one non-toxic polymer, each of said microparticles being in the form of a micromatrix with the theophylline uniformly distributed therethrough but not entirely coated by polymer, said particles having an average size of from 0.1 to 125 .mu.m, and an aqueous vehicle for suspending said microparticles comprising a substance, for inhibiting the release of theophylline from the microparticles when said microparticles are stored in said vehicle.
Dependencies are inferred from the claim text.