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US 5,352,890 AGranted
Quadrupole ion trap mass spectrometer having two axial modulation excitation input frequencies and method of parent and neural loss scanning
AssigneesUniversity of Florida, Finnigan Corporation
InventorsJodie V. Johnson, Randall E. Pedder, Richard A. Yost, Michael S. Story
Life of this patent
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Abstract
There is described a method of operating an ion trap mass spectrometer. The method is carried out by trapping ions of selected masses in a three-dimensional field and then generating at least two fields in said trap having different frequencies to excite multiple trapped ions.
Claims5
A mass spectrometry method including the steps of:
- a. establishing a trapping field capable of trapping parent ions and daughter ions within a trap region bounded by a set of electrodes;
- b. applying a low power supplemental AC voltage signal to the electrodes to induce dissociation of a first trapped parent ion, wherein the low power supplemental AC voltage signal has a first frequency matching a resonant frequency of the first trapped parent ion;
- c. applying a high power supplemental AC voltage signal to the electrodes to resonate a first daughter ion to a degree sufficient to enable detection of the first daughter ion, wherein the high power supplemental AC voltage signal has a second frequency matching a resonant frequency of the first daughter ion, wherein the high power supplemental AC voltage signal resonates the first daughter ion to a degree sufficient for detection by a detector comprising, or integrally mounted with at least one of the electrodes;
- and
- d. detecting the first daughter ion.
2 more elements
A mass spectrometry method including the steps of:
- a. establishing a trapping field capable of trapping parent ions and daughter ions within a trap region bounded by a set of electrodes;
- b. applying a low power supplemental AC voltage signal to the electrodes to induce dissociation of a first trapped parent ion, wherein the low power supplemental AC voltage signal has a first frequency matching a resonant frequency of the first trapped parent ion;
- and
- c. applying a high supplemental AC voltage signal to the electrodes to resonate a first daughter ion to a degree sufficient to enable detection of the first daughter ion, wherein the high power supplemental AC voltage signal has a second frequency matching a resonant frequency of the first daughter ion, wherein steps (b) and (c) are performed simultaneously.
1 more element
A mass spectrometry method including the steps of:
- a. establishing a three-dimensional quadrupole trapping field capable of trapping parent ions and daughter ions within a trap region bounded by a set of electrodes, and trapping parent ions in the trap region;
- b. then applying a low power supplemental AC voltage signal to the electrodes to induce dissociation of a first one of the parent ions to produce a first daughter ion, wherein the low power supplemental AC voltage signal has a first frequency matching a resonant frequency of the first one of the parent ions;
- and
- c. while performing step (b), applying a high power supplemental AC voltage signal to the electrodes to resonate the first daughter ion to a degree sufficient to enable detection thereof, wherein the high power supplemental AC voltage signal has a second frequency matching a resonant frequency of the first daughter ion.
1 more element
A mass spectrometry method including the steps of:
- a. establishing a three-dimensional quadrupole trapping field capable of trapping parent ions and daughter ions within a trap region bounded by a set of electrodes, and trapping parent ions in the trap region;
- b. then applying a lower power supplemental AC voltage signal to the electrodes to induce dissociation of a first species of the parent ions to produce first daughter ions, wherein the low power supplemental AC voltage signal has a first frequency matching a resonant frequency of the first species of the parent ions;
- c. while performing step (b), applying a high power supplemental AC voltage signal to the electrodes to resonate the first daughter ions to a degree sufficient to enable detection thereof, wherein the high power supplemental AC voltage signal has a second frequency matching a resonant frequency of the first daughter ions;
- d. after step (b), varying the frequency of the low power supplemental AC voltage signal to induce dissociation of different ones of the parent ions;
- and
- e. while performing step (d), continuing to apply said high power supplemental AC voltage signal to the electrodes to resonate daughter ions generated during step (d) to a degree sufficient to enable detection thereof.
3 more elements
Dependencies are inferred from the claim text.