9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids
AssigneeGist-Brocades N.V.
InventorsJacobus N. M. Batist, Arthur F. Marx, Willem J. van Zoest, Jagdish C. Kapur
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Abstract
New 9-alphahydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.
Claims5
17-Beta-cyano-9-alpha,17-alpha-dihydroxy-16-R-androst-4-en-3-one, where R is hydrogen, hydroxy, alphamethyl, beta-methyl or methylene.
17-Alpha-cyano-9-alpha,17-beta-dihydroxy-16-R-androst-4-en-3-one, where R is hydrogen, hydroxy, alphamethyl, beta-methyl or methylene.
17-Alpha-haloethynyl-9-alpha,17-beta-dihydroxy-16-R-androst-4-en-3-one, where halo is chlorine or bromine and R is hydrogen, hydroxy, alpha-methyl, beta-methyl or methylene.
17-Alpha-(1'-ethoxyethenyl)-3-methoxy-16-R-androsta-3,5-diene-9-alpha, 17-beta-diol where R is hydrogen, hydroxy, alpha-methyl, beta-methyl or methylene.
17.beta.-Cyano-9.alpha.,17.alpha.-dihydroxyandrost-4-en-3-one.
Dependencies are inferred from the claim text.