US 5,352,783 A · Microbial transformation product having immunosuppressive activity

Abstract

Microbial transformation of a macrolide immunosuppressant by the microorganism Streptomyces sp., (Merck Culture Collection MA 6960) ATCC No. 55387 yields a compound of the structural formula (I): ##STR1## This compound is an immunosuppressant useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

Claims1

Dependent claims

A compound of formula I:

##STR7## or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

08/074,258Filed 9 Jun 1993

Granted

4 Oct 1994

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07D 498/18
In which the condensed system contains three hetero rings: bridged systems
C12P 17/188
Containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin: heterocyclic…
C12P 19/445
Preparation of O-glycosides, e.g. glucosides: the saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
C07D
Heterocyclic compounds

Microbial transformation product having immunosuppressive activity

Life of this patent

Abstract

Claims1

Microbial transformation product having immunosuppressive activity

Life of this patent

Abstract

Claims1