US 5,352,685 A · Thieno[3,2-b]pyridine derivatives

Abstract

The thieno[3.2-b]pyridine derivative of the present invention promote the gastric emptying in male ddy mice and the gastric contraction in dogs sutured with a strain-gauge transducer. It is believed that the derivatives have the action to enhance gastric motor action and gastric emptying. Therefore, the compound of the present invention are effective for the prevention and therapeutical treatment of the symptoms caused by gastric hypanakinesis, such as heartburn, abdominal distension feeling, anorexia, unpleasant feeling on upper abdomen, abdominalgia, nausea, vomiting, etc. caused by the underlying diseases such as acute and chronic gastritis, stomach and duodenum ulcer, gastroneurosis, gastroptosis, etc. The present invention also encompasses a pharmaceutical composition containing as the effective ingredient a compound of the present invention, and a method for producing the same.

Claims21

Dependent claims

A thieno[3,2-b]pyridine derivative represented by formula (I):

##STR22## wherein Y represents --O-- or ##STR23## (wherein R.sup.3 represents hydrogen atom or a C.sub.1 -C.sub.6 alkyl group);
R.sup.1 represents hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.2 -C.sub.6 alkenyl group, a C.sub.2 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.6 -C.sub.12 aryl group, or a C.sub.7 -C.sub.18 aralkyl group;
R.sup.2 represents hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, halogen atom, hydroxyl group, a C.sub.1 -C.sub.6 alkoxyl group, amino group, a C.sub.1 -C.sub.6 alkylamino group, nitro group, mercapto group or a C.sub.1 -C.sub.6 alkylthio group;
and A is represented by ##STR24## (wherein n is an integer of 1 to 4;
R.sup.4 represents hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group or a C.sub.7 -C.sub.18 aralkyl group);
a pharmaceutically acceptable salt thereof;
an N-oxide derivative or a solvate thereof.

4 more elements

Dependencies are inferred from the claim text.

Thieno[3,2-b]pyridine derivatives

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Thieno[3,2-b]pyridine derivatives

Life of this patent

Abstract

Claims21