Pyridines as medicaments

A pyridine compound of formula I ##STR76## wherein one of the radicals R1 and R5 denotes 1-6C-alkyl and the other denotes the grouping -E1-E2-N(R6a)R6b

• R2 denotes hydrogen, 1-6C-alkyl or, together with R3, 2-3C-alkylene,
• R3 denotes 1-4C-alkyl, 1-4C-alkoxy, 3-5C-alkoxyalkyl, 3-5C-alkoxyalkoxy or, together with R2, 2-3C-alkylene,
• R4 denotes phenyl which is substituted by R41 and R42,
• R41 denotes hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, 1-4C -alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is completely or partly substituted by fluorine, 1-4C-alkoxycarbonyl, 2-5C-acyl, amino or mono- or di-1-4--C-alkylamino,
• R42 denotes hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is completely or partly substituted by fluorine, 1-4C-alkoxycarbonyl, 2-5C-acyl;
• amino or mono-or di-1-4C-alkylamino,
• E1 denotes methylene (CH.sub.2),
• E2 denotes straight-chain or branched 1-7C-alkylene, the grouping -(CH.sub.2).sub.m -E-(CH.sub.2).sub.n -or the grouping -A1-O-A2-,
• E denotes vinylene (--CH.dbd.CH--) or ethinylene (--C.dbd.C-),
• m denotes the number 1 or 2,
• n denotes the number 1 or 2,
• A1 denotes a bond or 2-4C-alkylene,
• A2 denotes 2-4C-alkylene or 2C-alkylenoxy-2C-alkylene,
• R6a l and R6b, together and including the nitrogen atom to which they are both bonded, represent a radical of the formula ##STR77## wherein A denotes --CH.sub.2 --CH.sub.2 C(R7)R8--CH.sub.2 --CH.sub.2 -, --CH.sub.2 --CH.sub.2 CHR9--CH.sub.2 --CH.sub.2 - or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CHR10-,
• R7 denotes hydrogen (H) or aryl and
• R8 denotes aryl,
• or
• R7 and R8 together denote diarylmethylene,
• R9 denotes diaryl-1-4C-alkyl and
• R10 denotes aryl-1-4C-alkyl,
• wherein
• aryl represent a ring of the formula ##STR78## wherein R11 and R12 are identical or different and denote hydrogen (H), 1-4C-alkyl, 1-4C-alkoxy, halogen, hydroxyl, trifluoromethyl or, together, methylenedioxy, or salt thereof.