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US 5,352,682 AGranted
Compositions containing salts of bile acid-aminosalicylate conjugates
AssigneeDigestive Care Inc.
InventorTibor Sipos
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AssigneeDigestive Care Inc.
InventorTibor Sipos
Estimating the term…
Disclosed are compositions containing bile acid-aminosalicylate conjugates having the formula, or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.1 is OH either the .alpha. or the .beta. position; R.sub.2 is OH; R.sub.3 is H or OH; and R.sub.4 is H or acetyl, the process for their preparation and method of treating/preventing gastrointestinal disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, colon cancer, inflammatory bowel diseases, Crohn's disease, cystic fibrosis, dissolving gallstones, and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.
A method of treating/preventing bile acid deficiency condition and inflammatory disease in a patient comprising the administration to said patient in need of such treatment/prevention an effective amount of a pharmaceutically acceptable bile acid-aminosalicylic acid conjugate of the formula (I) or a pharmaceutically acceptable salt thereof ##STR4## wherein R.sub.1 is OH either in the .alpha. or in the .beta. position;
Dependencies are inferred from the claim text.