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US 5,352,678 AGranted
Antiischemic piperazinyl- and piperidinyl-cyclohexanes
AssigneeBristol-Myers Squibb Company
InventorsRonald J. Mattson, John D. Catt
Life of this patent
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Abstract
Certain piperazinyl- and piperidinyl-substituted cyclohexanes have anti-ischemic properties.
Claims12
A dopaminergic compound of Formula I or a pharmaceutically acceptable salt or hydrate thereof:
- ##STR30## wherein R=R.sub.1 and is independently H or halogen;
- or R and R.sub.1 may be taken together to form an --O(CH.sub.2).sub.m O-- (m=1 or 2);
- X=a phenyl residue;
- Y=N;
- R.sub.2 =R.sub.3 and is independently H or C.sub.1-4 alkyl;
- and
- R.sub.4 =phenyl or substituted phenyl wherein the phenyl group is mono-, di- or di-substituted with groups selected from:
- F, Cl, I and C.sub.1-4 alkoxy.
5 more elements
Dependencies are inferred from the claim text.