Pseudorabies virus protein
AssigneeThe Upjohn Company
InventorsErik A. Petrovskis, Leonard E. Post, James G. Timmins
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Abstract
The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
Claims5
A method for distinguishing an animal vaccinated with a pseudorabies virus (PRV) vaccine lacking glycoprotein gI or gp63 from an animal infected with a virulent wild-type pseudorabies virus without sacrificing the animal comprising:
- contacting serum from the animal with PRV glycoprotein gI or gp63, and detecting the presence or absence of antibodies which specifically bind to PRV glycoprotein gI or gp63 wherein the presence of antibodies indicates that the animal has been infected with a virulent wild-type pseudorabies virus.
Dependencies are inferred from the claim text.