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US 5,352,574 AGranted
Surface functionalized and derivatized electroactive polymers with immobilized active moieties
OwnerAnthony Guiseppi-Elieinventor
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OwnerAnthony Guiseppi-Elieinventor
Estimating the term…
New variants of electroactive and optoactive polymers are formed from the surface chemical modification and derivization of free-standing and substrate-supported polymer films. The free-standing or substrate-supported films are chemically modified at or near their surfaces to introduce hydrophilic and/or reactive functional groups, such as carboxylic acids, hydroxyls, and amines. Surface derivatization of the modified polymer film is achieved through the specific attachment of bioactive, immunoactive, electroactive, and catalytic agents to the surface of the electroactive or optoactive polymer film. In one embodiment, a polymer selected from polyacetylene, polypyrrole, polyanilane and polythiophene is modified to contain functional groups and an indicator reagent is covalently coupled to the functional groups. When an analyte in a sample reacts with the indicator reagent, electrical conductivity of the polymer is changed and presence of the analyte is indicated by the change in electrical conductivity.
A process for the immobilization of an indicator reagent upon a chemically modified surface of an electroactive polymeric substrate having a predetermined electrical conductivity, the process comprising:
A method for detecting the presence of an analyte in a sample comprising contacting a sample with a material comprising an electroactive polymeric substrate having a predetermined electrical conductivity containing a covalently bound indicator reagent, reacting analyte in the sample with the indicator reagent to change the electrical conductivity of the suffererate and from the change in the electrical conductivity determining the presence of the analyte, said material being prepared by reacting an electroactive polymeric substrate selected from the group consisting of polyacetylene, polypyrrole, polyaniline and polythiophene having a predetermined electrical conductivity at least one chemical modification reagent to produce an activated surface containing new functional groups capable of covalent bonding on the surface of the substrate and having a predetermined electrical conductivity, and reacting the new functional groups of the activated surface with an indicator reagent to covalently bond the indicator reagent to the surface of the substrate.
A material comprising;
Dependencies are inferred from the claim text.