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US 5,352,453 AGranted
Compositions containing non-glycosylated human tissue type plasminogen activator
AssigneeBoehringer Mannheim GmbH
InventorsUlrich Kohnert, Rainer Rudolph
Life of this patent
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Abstract
Pharmaceutical compositions containing non-glycosylated human tissue type plasminogen activator (t-PA) having enzymatic activity of at least 0.1 MU/ml are disclosed. The compositions have a pH of from 4.5 to 6, contain citrate, and at least one other compound.
Claims25
A composition having human tissue type plasminogen activator (t-PA) activity consisting essentially of a non-glycosylated t-PA pro having enzymatic activity of at least 0.1 MU/ml, a citrate and at least one compound selected from the group consisting of:
- (a) ascorbic acid;
- (b) EDTA;
- (c) an amino compound selected from the group consisting of taurine, 4-aminobutanol-1, 5-aminopentanol-1, 6-aminohexanol-1, 1,9-diaminononane, 1,8-diaminooctane, 1,7-diaminoheptane, 1,6-diaminohexane, 1,5-diaminopentane, 1,4-diaminobutane, 1,3-diaminopropane, lysine, ornithine, 8-aminooctanoic acid, 7-diaminoheptanoic acid, .epsilon.-aminocaproic acid, .epsilon.-aminovaleric acid, .delta.-aminobutyric acid, tranexamic acid and p-aminomethylbenzoic acid;
- (d) guanidinobytric acid;
- (e) dimethylbiguanide;
- (f) a pyrimidine nucleoside;
- (g) a pyrimidine nucleotide;
- and
- (h) a carboxylic acid substituted at least once with a hydroxyl group, keto group, or a carboxyl group wherein said composition has a pH of from 4.5 to 6.
6 more elements
Dependencies are inferred from the claim text.