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US 5,350,867 AGranted
Inhibitors of farnesyl protein transferase
AssigneeMerck & Co., Inc.
InventorSheo B. Singh
Life of this patent
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Abstract
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Claims3
A compound, which inhibits farnesyl-protein transferase, of the formula:
- ##STR7## wherein:
- X--X is
- CH.dbd.CH(cis);
- CH.dbd.CH(trans);
- or
- CH.sub.2 CH.sub.2 ;
- R.sup.1 and R.sup.2 are each independently selected from:
- a) H;
- b) C.sub.1-5 alkyl;
- c) C.sub.1-5 alkyl substituted with a member of the group consisting of:
- i) phenyl;
- ii) phenyl substituted with methyl, methoxy, halogen, (Cl, Br, F, I) or hydroxy;
- or a pharmaceutically acceptable salt of a compound of formula (II) in which at least one of R.sup.1 and R.sup.2 is hydrogen.
10 more elements
Dependencies are inferred from the claim text.