Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsKenneth B. Seamon, Joan Robbins, Antonio Laurenza
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Abstract
The subject matter of the present invention relates to aminoalkylcarbamates of forskolin and the methods of using these compounds. Specifically, the aminoalkylcarbamates may be utilized in the synthesis of forskolin derivatives. The final derivatives may, in turn, be used in the development of in vivo and in vitro assays designed to study different proteins.
Claims5
A carbamate derivative of forskolin of the formula:
- ##STR8## wherein R is CONH(R.sub.1)NH.sub.2 ;
- R.sub.1 is a hydrocarbon group of the formula
- (CH.sub.2).sub.n or CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ;
- and
- n=1, 2, 4, 5 or 7.
A 6-carbamate derivative of forskolin of the formula:
- ##STR9## wherein R is CONH(R.sub.1)NH.sub.2 ;
- R.sub.1 is a hydrocarbon group of the formula (CH.sub.2).sub.n or
- CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ;
- and
- n=1, 2, 4, 5, or 7.
A 7carbamate derivative of forskolin of the formula:
- ##STR10## wherein R is CONH(R.sub.1)NH.sub.2 ;
- R.sub.1 is a hydrocarbon group of the formula (CH.sub.2).sub.n or
- CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ;
- and
- n=1, 2, 4, 5, or 7.
A 1-carbamate derivative of forskolin of the formula:
- ##STR11## wherein R is CONH(R.sub.1)NH.sub.2 ;
- R.sub.1 is a hydrocarbon group of the formula (CH.sub.2).sub.n or
- CH.sub.2 H.dbd.CH(CH.sub.2).sub.n ;
- and
- n=1, 2, 4, 5, or 7.
A 9-carbamate derivative of forskolin of the formula:
- ##STR12## wherein R is CONH(R.sub.1)NH.sub.2 ;
- R.sub.1 is a hydrocarbon group of the general formula
- (CH.sub.2).sub.n or CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ;
- and
- n=1, 2, 4, 5, or 7.
Dependencies are inferred from the claim text.