2-substituted tertiary carbinol derivative of 1,5-iminosugars
AssigneeG. D. Searle & Co.
InventorsIsh K. Khanna, Richard A. Mueller, Richard M. Weier
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Abstract
Novel 2-alkyl carbinol derivatives of deoxynojirimycin (DNJ) and the chemical synthesis of these derivatives and intermediates therefor from DNJ and their method of inhibiting lentiviruses are disclosed.
Claims27
A compound of the formula ##STR16## wherein R.sub.3 =MEM, SEM, TBDMS or CH.sub.3, and Z is COOCH.sub.2 Ph.
A compound of the formula ##STR17## wherein R.sub.3 =MEM, SEM, TBDMS or CH.sub.3, and Z is COOCH.sub.2 Ph.
A compound of the formula ##STR18## wherein R.sub.3 =MEM, SEM, TBDMS or CH.sub.3, and Z is COOCH.sub.2 Ph.
A compound of the formula ##STR19## wherein Z is COOCH.sub.2 Ph.
A compound of the formula ##STR20## wherein Z is COOCH.sub.2 Ph and R.sub.3 is CH.sub.3 or MEM and R.sub.4 is CH.sub.3.
A compound of the formula ##STR21## wherein Z is COOCH.sub.2 Ph.
A compound of the formula ##STR22##
A compound of the formula ##STR23## wherein R.sub.3 =H or SiMe.sub.2 (t-Bu), and Z is COOCH.sub.2 Ph.
A compound of the formula ##STR24## wherein R.sub.3 =H or SiMe.sub.2 (t-Bu), and Z is COOCH.sub.2 Ph.
A compound selected from the group consisting of a 2-epoxide derivative of 1-deoxynojirimycin having the formula ##STR25## wherein Z is COOCH.sub.2 Ph.
A compound selected from the group consisting of 2-methyl carbinol derivatives having the formula ##STR26## wherein Z is COOCH.sub.2 Ph.
Dependencies are inferred from the claim text.