Compounds and methods for treating hyperproliferative skin disease

A method of treating psoriasis or eczema in a mammal, comprising administering in combination with a pharmaceutically acceptable carrier a compound having the structural formula:

• ##STR8## wherein n is 1, 2 or 3;
• R.sup.4 and R.sup.5 are hydrogen, methyl or ethyl and Q' is hydrogen, hydroxy, alkyl having from 1 to 6 carbon atoms, halogen, nitro, alkoxy having from 1 to 6 carbon atoms, halogen, nitro, having from 3 to 7 carbon atoms, alkenyloxy having from 3 to 6 carbon atoms, alkynyloxy having from 3 to 6 carbon atoms, S(O).sub.m -R.sup.a {wherein m is 0, 1 or 2 and R.sup.a is alkyl having from 1 to 6 carbon atoms}, NHSO.sub.2 R.sup.a {wherein R.sup.a is defined herein}, NHSO.sub.2 CF.sub.3, SO.sub.2 NH.sub.2, COR.sup.b {wherein R.sup.b is OH, NH.sub.2 or OR.sup.a (wherein R.sup.a is defined herein)}, O-B-COR.sup.b {wherein B is alkanediyl having from 1 to 4 carbon atoms and R.sup.b is defined herein}, or NHCOR.sub.c {wherein R.sup.c is hydrogen, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms, COR.sup.d (wherein R.sup.d is hydroxy or alkoxy having from 1 to 6 carbons atoms) or NHR.sup.e (wherein R.sup.e is hydrogen or alkyl having from 1 to 6 carbon atoms)}.