Pharmaceutical combination preparations containing cephalosporin and xanthine derivatives and their use
AssigneeHoechst Aktiengesellschaft
InventorsNorbert Klesel, Michael Limbert, Elmar Schrinner
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Abstract
Pharmaceutical combination preparations containing cefotaxime and at least one xanthine derivative are suitable for the treatment of bacterial infectious diseases and for the treatment of septic shock.
Claims6
A composition containing an effective amount of cefotaxime and at least one xanthine derivative selected from the group consisting of
- 1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine,
- 3-methyl-1-(5-oxohexyl)-7-propylxanthine,
- 7-propyl-1-(5-hydroxy-5-methylhexyl)-3-methylxanthine,
- 7-ethoxymethyl-1-(5-hydroxy-5-methylhexyl)-3-methylxanthine, 3-methyl-l-(5-oxohexyl)-7-(2-oxopropyl)-xanthine and
- 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine.
(Amended) A method for treatment of bacterial infectious diseases comprising administering to a host in need thereof an effective amount of cefotaxime and at least one xanthine derivative selected from the group consisting of
- 1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine,
- 3-methyl-1-(5-oxohexyl)-7-propylxanthine,
- 7-propyl-1-(5-hydroxy-5-methylhexyl)-3-methylxanthine,
- 7-ethoxymethyl-1-(5-hydroxy-5-methylhexyl)-3-methylxanthine,
- 3-methyl-1-(5-oxohexyl)-7-(2-oxopropyl)-xanthine and
- 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine.
A method for treatment of septic shock comprising administering to a host in need thereof an effective amount of cefotaxime and at least one xanthine derivative selected from the group consisting of
- 1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine,
- 3-methyl-1-(5-oxohexyl)-7-propylxanthine,
- 7-propyl-1-(5-hydroxy-5-methylhexyl)-3-methylxanthine,
- 7-ethoxymethyl-1-(5-hydroxy-5-methylhexyl)-3-methylxanthine,
- 3-methyl-1-(5-oxohexyl)-7-(2-oxopropyl)-xanthine and
- 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine.
Dependencies are inferred from the claim text.