3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion

A method of treating diseases mediated by inhibiting the adhesion of leukocytes to endothelial cells selected from the group consisting of rheumatoid arthritis, asthma and psoriasis comprising administering to a host in need thereof a therapeutically effective amount in unit dosage form of a compound of the formula ##STR11## wherein R.sub.1 is hydrogen;

• lower alkyl, or lower alkyl substituted by halogen;
• phenyl, or phenyl substituted by hydroxy, halogen, lower alkyl, lower alkoxy, or CO.sub.2 R.sub.7 where R.sub.7 is hydrogen or lower alkyl;
• benzyl, or benzyl substituted by hydroxy, halogen, lower alkyl, lower alkoxy, or CO.sub.2 R.sub.7 as defined above;
• n is an integer from 0 to 2;
• m is an integer from 0 to 6;
• X is S(O).sub.n or NR.sub.2 in which R.sub.2 is hydrogen, lower alkyl, phenyl, benzyl, substituted lower alkyl as defined above, substituted phenyl as defined above, substituted benzyl as defined above;
• and
• R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are each independently hydrogen, hydroxy, halogen, lower alkyl, trifluoromethyl, lower alkoxy, phenyl, benzyloxy, nitro, or --NR.sub.7 R.sub.2 in which R.sub.7 and R.sub.2 are as defined above;
• or a pharmaceutically acceptable acid addition or base salt thereof.