Treatment of myocardial failure
AssigneeLunar Corporation
InventorsCarl E. Gulbrandsen, Richard L. Moss
Life of this patent
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Abstract
Method of increasing the strength of contraction in the mammalian heart muscle by administering to the mammal an effective amount of an activated Vitamin D compound, i.e. a 1.alpha.-hydroxylated Vitamin D compound which binds with the Vitamin D receptor and produces a positive inotropic effect in the heart muscle. The activated Vitamin D compound may be given as a means to treat myocardial failure.
Claims4
A method for preventing or treating myocardial failure in a mammal comprising administering to said mammal an effective amount of a compound of the general structure of Formula I wherein A and B are either hydrogen or a carbon to carbon bond thus forming a double bond between C22 and C23, R.sub.2, and R.sub.3 can be either hydrogen, hydroxy, lower alkyl, O-lower alkyl, O-lower acyl, O-aromatic acyl or flouro, and where R.sub.4 is hydrogen or lower alkyl along with an acceptable excipient. ##STR2##
A method for increasing the strength of the contraction in the heart of a mammal comprising administering to said mammal an effective amount of a compound of the general structure of formula I wherein A and B are either hydrogen or a carbon to carbon bond thus forming a double bond between C22 and C23, R.sub.2, and R.sub.3 can be either hydrogen, hydroxy, lower alkyl, O-lower alkyl, O-lower acyl, O-aromatic acyl or flouro, and where R.sub.4 is hydrogen or lower ##STR3## alkyl along with an acceptable excipient.
Dependencies are inferred from the claim text.