Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis

A compound of the formula:

• ##STR17## wherein:
• R.sup.1,R.sup.5, and R.sup.11 is each independently H, OH, lower alkyl, or lower alkoxy;
• R.sup.2 is H, lower alkyl, or together with R.sup.1 forms a double bonded oxygen (.dbd.O);
• R.sup.3 is H, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, or is joined to R.sup.1 to form a carbon bridge of 2 or 3 carbon atoms or a mono-oxa carbon bridge of 1 or 2 carbon atoms, said bridge optionally containing a double bond;
• R.sup.4, R.sup.12, and R.sup.14 is each independently H or lower alkyl;
• R.sup.6 is H or lower alkyl, or two R.sup.6 groups on the same or adjacent carbons can form a saturated ring of 3 to 8 members;
• R.sup.7 is H, OH, lower alkyl, lower alkoxy, lower alkylthio, or lower alkylcarbonyloxy;
• R.sup.8 is H, halogen, lower alkyl, lower alkoxy, CF.sub.3, CN, COR.sup.14, or a non-bonded electron pair;
• R.sup.9 and R.sup.10 is each independently H, lower alkyl, lower alkoxy, hydroxy lower alkyl, lower alkoxy lower alkyl, lower alkylthio lower alkyl, lower alkylthio lower alkylcarbonyl, (R.sup.8)2-phenylthio lower alkyl, halogen, CN, NO.sub.2, CF.sub.3, N.sub.3, N(R.sup.13).sub.2, NR.sup.13 COR.sup.14, NR.sup.13 CON(R.sup.13).sub.2, SR.sup.15, S(O)R.sup.15, S(O).sub.2 R.sup.15, S(O).sub.2 N(R.sup.13).sub.2, COR.sup.14, CON(R.sup.13).sub.2, CO.sub.2 R.sup.14, C(R.sup.14).sub.2 OC(R.sup.14).sub.2 -CO.sub.2 R.sup.14, or C(R.sup.14).sub.2 CN;
• R.sup.10 is attached to either ring of the naphthalene ring system;
• R.sup.13 is H, or lower alkyl, or two R.sup.13 groups attached to the same nitrogen may form a saturated ring of 5 or 6 members, optionally containing a second heteroatom chosen from O, S or NR.sup.4 ;
• R.sup.15 is lower alkyl, phenyl-(R.sup.8).sub.2, or CF.sub.3 ;
• X.sup.1 is O;
• X.sup.2 is C(R.sup.6).sub.2 ;
• X.sup.3 is C(R.sup.6).sub.2 O;
• Ar is phenyl(R.sup.9).sub.2 ;
• Het is pyridyl-(R.sup.8).sub.2 and
• m is 1;
• or a pharmaceutically acceptable salt thereof.