Antibodies which bind to novel lymphokine related peptides
AssigneeCiba-Geigy Corporation
InventorsKarel G. Odink, Roger Clerc, Nico Cerletti, Josef Bruggen, Lajos Tarcsay, Clemens Sorg, Walter Wiesendanger
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Abstract
The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for said polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to said polypeptides , and diagnostic methods for inflammatory conditions and cystic fibrosis.
Claims5
A monoclonal antibody which specifically binds to human macrophage inhibition factor related peptide MRP-14 of the formula (II) ##STR14## wherein Z.sub.2 is hydrogen, acyl or an optionally acylated peptide residue of 1 to 5 amino acids and wherein said antibody does not crossreact with human macrophage inhibition factor related peptide MRP-8 of the formula (I) ##STR15## wherein Z.sub.1 is hydrogen, acyl or the amino acid residue methionine, or a derivative of said antibody which retains the binding pattern of the parent antibody and is selected from the group consisting of antibody fragments, radioactively labelled antibodies, and conjugates of said antibody with enzymes, biotin, avidin, fluorescent markers, chemiluminescent markers and paramagnetic particles.
Dependencies are inferred from the claim text.