Back to results
US 5,350,584 AGranted
Spheronization process using charged resins
AssigneeMerck & Co., Inc.
InventorsGregory A. McClelland, Gaylen M. Zentner
Life of this patent
Estimating the term…
Abstract
The invention comprises a novel process for the spheronization of charged resins. Spherical multiparticlates are produced which range in size from 0.3 mm to 3 mm in diameter. The spherical particle product is microcrystalline-free. The process consists of the steps of mixing followed by wet granulation, spheronization and drying.
Claims13
A process for the production of microcrystalline cellulose free multiparticulate comprise a medicament and a charged resin, comprising the steps of:
- (a) adding a charged resin and an excipient to a mixing vessel;
- (b) mixing the charged resin and excipient of (a) to obtain a uniform formulation;
- (c) adding a granulating solution to wet the dry mixture of (b);
- (d) granulating the mixture until a uniform, wet granulation results;
- (e) extruding the wet granulation of (d) through a screen to produce strands;
- (f) spheronizing the strands of (e) to produce microcrystalline cellulose free spherical multiparticulates;
- (g) collecting and drying the spherical multiparticulates.
4 more elements
Dependencies are inferred from the claim text.