Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
AssigneeKRKA, tovarna zdravil, p.o.
InventorsMarjo Merslavic, Jozica Razen, Ales Rotar
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Abstract
There is disclosed a stable formulation of enalapril salt of the formula I ##STR1## which is prepared in such manner that a compound of formula II ##STR2## is suspended in demineralized water and a stoichiometric amount of the corresponding sodium compound such as sodium carbonate, sodium hydrogen carbonate or sodium hydroxide is added thereto, to this enalapril sodium salt prepared in situ of the formula I ##STR3## formulating additives are added, the whole is homogenized and formulated.
Claims13
Process for preparing stable formulation of enalapril sodium salt of the formula I ##STR7## characterized in that enalapril mileate of formula II ##STR8## is suspended in demineralized water and a stoichiometric amount of the corresponding sodium compound selected from the group consisting of sodium carbonate, sodium hydrogen carbonate and sodium hydroxide is added thereto, to this enalapril sodium salt prepared in situ of the formula I ##STR9## formulating additives are added, the whole is homogenized and formulated.
Dependencies are inferred from the claim text.