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AssigneeCommonwealth Scientific and Industrial Research Organization
InventorsAhmed A. Azad, Mittur N. Jagadish, Kevin J. Fahey
Estimating the term…
A recombinant DNA molecule comprising a nucleotide sequence coding for a conformational epitope of the VP2 polypeptide of IBDV. In particular, a DNA molecule comprising a sequence which substantially corresponds to the AccI-SpeI fragment, and optionally the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide. Synthetic peptides or polypeptides, including fused polypeptides, prepared by expression of host cells containing these DNA molecules are also disclosed, as well as compositions for stimulating an immune response against IBDV comprising at least one such synthetic peptide or polypeptides.
A recombinant DNA molecule consisting essentially of a nucleotide sequence coding for a non-full length fragment of VP2 polypeptide of IBDV including a conformational epitope of the VP2 polypeptide, said conformational epitope encoded by the AccI-SpeI fragment, optionally together with the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide.
A synthetic peptide or polypeptide having the antigenicity of a non-full length fragment of the VP2 polypeptide of IBDV including a conformational epitope of the VP2 polypeptide, said conformational epitope encoded by the AccI-SpeI fragment, optionally together with the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide.
A fused polypeptide comprising a polypeptide having the antigenicity of a non-full length fragment of the VP2 polypeptide of IBDV including a conformational epitope of the VP2 polypeptide, said conformational epitope encoded by the AccI-SpeI fragment, optionally together with the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide as the C-terminal sequence, and an additional non-IBDV polypeptide encoded by an expression vehicle or vector as the N-terminal sequence fused thereto.
A composition for stimulating an immune response against IBDV, which comprises at least one synthetic peptide or polypeptide having the antigenicity of a non-full length fragment of the VP2 polypeptide of IBDV including a conformational epitope of the VP2 polypeptide, said conformational epitope encoded by the AccI-SpeI fragment, optionally together with the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide, together with a pharmaceutically acceptable carrier therefor.
A composition for stimulating an immune response against IBDV, which comprises a fused polypeptide comprising a polypeptide having the antigenicity of a non-full length fragment of the VP2 polypeptide of IBDV including a conformational epitope of the VP2 polypeptide, said conformational epitope encoded by the AccI-SpeI fragment, optionally together with the ScaI-XhoI fragment of the IBDV genome segment coding for the VP2 polypeptide as the C-terminal sequence, and an additional non-IBDV polypeptide encoded by an expression vehicle or vector as the N-terminal sequence fused thereto, together with a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.