US 5,349,068 A · 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Abstract

Compounds of the formula ##STR1## wherein: R.sub.1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl or hydroxyalkoxy; Y is alkylene of 3 to 9 carbon atoms, R.sub.2 and R.sub.3 independently are hydrogen, alkyl, alkoxy, halo, trifluoromethyl and nitro; R.sub.4 is alkoxy, hydroxy, halomethyl, dihalomethyl, trihalomethyl, cycloalkyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, alkanecarbonyloxyalkyl, cyano, 2,2,2-trifluoroethyl, (4-methylphenyl)sulfonyloxymethyl, N.dbd.Q or CON.dbd.Q, where N.dbd.Q is amino, alkylamino or dialkylamino; or pharmaceutically acceptable acid-addition salts thereof are useful as antiviral agents.

Claims1

Dependent claims

A process for preparing a compound of formula;

##STR25## wherein;
R.sub.1 is alkyl, alkoxy, cycloalkyl or alkoxyalkyl;
Y is alkylene of 3 to 9 carbon atoms,
R.sub.2 and R.sub.3 independently are hydrogen, alkyl, alkoxy, halo, trifluoromethyl or nitro;
R.sub.4 is 2,2,2-trifluoroethyl,
which comprises reacting a compound of formula ##STR26## wherein R1, R2 and R3 are as described above with 2-trifluoroethylidene-1,3-dithiane in the presence of silver trifluoroacetate.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

07/869,287Filed 15 Apr 1992

Granted

20 Sep 1994

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07D 413/10
Containing two hetero rings: linked by a carbon chain containing aromatic rings
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 413/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms:…

1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Life of this patent

1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Life of this patent

Abstract

Claims1