Modified interluekin-1.beta.
AssigneeUniversity of Maryland
InventorBalasubramanian Veerapandian
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Abstract
The present invention relates to modified forms of IL-1.beta. with altered IL-1.beta. activity. The modified IL-1.beta. is the result of mutations which affect amino acids in the beta barrel portion of the IL-1.beta. structural formula. The invention also relates to expression systems that will produce the modified IL-1.beta. polypeptides, and methods of treating susceptible diseases with the modified IL-1.beta. polypeptides.
Claims3
A modified interleukin-1.beta. polypeptide antagonist which inhibits the biological activity of interleukin-1.beta., said polypeptide having the same amino acid sequence as IL-1.beta. but having an aliphatic chain amino acid at the 25 position of the amino acid sequence.
Dependencies are inferred from the claim text.